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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50102271
Substrate
n/a
Meas. Tech.
ChEMBL_196191 (CHEMBL803636)
Ki
9±n/a nM
Citation
 Campiani, G; Aiello, F; Fabbrini, M; Morelli, E; Ramunno, A; Armaroli, S; Nacci, V; Garofalo, A; Greco, G; Novellino, E; Maga, G; Spadari, S; Bergamini, A; Ventura, L; Bongiovanni, B; Capozzi, M; Bolacchi, F; Marini, S; Coletta, M; Guiso, G; Caccia, S Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. J Med Chem 44:305-15 (2001) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50102271
Synonyms:
1-(5-Bromo-pyridin-2-yl)-3-[2-(4-oxo-4H-5,9,9b-triaza-cyclopenta[a]naphthalen-5-yl)-ethyl]-thiourea | CHEMBL107535
Type:
Small organic molecule
Emp. Form.:
C18H15BrN6OS
Mol. Mass.:
443.32
SMILES:
Brc1ccc(NC(=S)NCCn2c3cccnc3n3cccc3c2=O)nc1
Structure:
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