Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50067116
Substrate
n/a
Meas. Tech.
ChEMBL_30020 (CHEMBL641311)
Ki
>10000±n/a nM
Citation
 van Muijlwijk-Koezen, JE; Timmerman, H; Vollinga, RC; Frijtag von Drabbe Künzel, J; de Groote, M; Visser, S; IJzerman, AP Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists. J Med Chem 44:749-62 (2001) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_RAT | ADENOSINE A2a | Adenosine A2 receptor | Adenosine A2a receptor (A2a) | Adenosine Receptors A2a (A2a) | Adenosine receptor A2a and A3 | Adenosine receptors A2a | Adora2a | Rat striatal adenosine A2a receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45015.65
Organism:
Rattus norvegicus (rat)
Description:
Rat A2A receptors expressed in CHO cells.
Residue:
410
Sequence:
MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
  
Inhibitor
Name:
BDBM50067116
Synonyms:
4-Methoxy-N-(3-pyridin-2-yl-isoquinolin-1-yl)-benzamide | 4-methoxy-N-(3-(pyridin-2-yl)isoquinolin-1-yl)benzamide | CHEMBL128929 | VUF-8504
Type:
Small organic molecule
Emp. Form.:
C22H17N3O2
Mol. Mass.:
355.3893
SMILES:
COc1ccc(cc1)C(=O)Nc1nc(cc2ccccc12)-c1ccccn1
Structure:
Search PDB for entries with ligand similarity: