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Target
B2 bradykinin receptor
Ligand
BDBM50409528
Substrate
n/a
Meas. Tech.
ChEMBL_40444 (CHEMBL652383)
Ki
176±n/a nM
Citation
 Dziadulewicz, EK; Ritchie, TJ; Hallett, A; Snell, CR; Davies, JW; Wrigglesworth, R; Dunstan, AR; Bloomfield, GC; Drake, GS; McIntyre, P; Brown, MC; Burgess, GM; Lee, W; Davis, C; Yaqoob, M; Phagoo, SB; Phillips, E; Perkins, MN; Campbell, EA; Davis, AJ; Rang, HP Nonpeptide bradykinin B2 receptor antagonists: conversion of rodent-selective bradyzide analogues into potent, orally-active human bradykinin B2 receptor antagonists. J Med Chem 45:2160-72 (2002) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BK-2 receptor | BKRB2_RAT | Bdkrb2 | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44941.22
Organism:
RAT
Description:
B2 BRADYKININ BDKRB2 RAT::P25023
Residue:
396
Sequence:
MDTRSSLCPKTQAVVAVFWGPGCHLSTCIEMFNITTQALGSAHNGTFSEVNCPDTEWWSWLNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIYLGNLAAADLILACGLPFWAITIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWSCTLLLSSPMLVFRTMKDYREEGHNVTACVIVYPSRSWEVFTNMLLNLVGFLLPLSIITFCTVRIMQVLRNNEMKKFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTLLRLGVLSGCWNERAVDIVTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGGCMGESVQMENSMGTLRTSISVDRQIHKLQDWAGNKQ
  
Inhibitor
Name:
BDBM50409528
Synonyms:
CHEMBL2112220
Type:
Small organic molecule
Emp. Form.:
C35H42N8O6S
Mol. Mass.:
702.823
SMILES:
CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc23)c(c1)[N+]([O-])=O
Structure:
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