Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50108699
Substrate
n/a
Meas. Tech.
ChEMBL_2290 (CHEMBL617075)
Ki
0.42±n/a nM
Citation
 Fletcher, SR; Burkamp, F; Blurton, P; Cheng, SK; Clarkson, R; O'Connor, D; Spinks, D; Tudge, M; van Niel, MB; Patel, S; Chapman, K; Marwood, R; Shepheard, S; Bentley, G; Cook, GP; Bristow, LJ; Castro, JL; Hutson, PH; MacLeod, AM 4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists. J Med Chem 45:492-503 (2002) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50108699
Synonyms:
1-(2,4-difluorophenethyl)-4-(4-fluorophenylsulfonyl)piperidine | 1-(2-(2,4-Difluorophenyl)ethyl)-4-(4-fluorophenylsulfonyl)piperidine | 1-[2-(2,4-Difluoro-phenyl)-ethyl]-4-(4-fluoro-benzenesulfonyl)-piperidine | CHEMBL358075
Type:
Small organic molecule
Emp. Form.:
C19H20F3NO2S
Mol. Mass.:
383.428
SMILES:
Fc1ccc(cc1)S(=O)(=O)C1CCN(CCc2ccc(F)cc2F)CC1
Structure:
Search PDB for entries with ligand similarity: