Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50108704
Substrate
n/a
Meas. Tech.
ChEMBL_2622 (CHEMBL621534)
Ki
3.2±n/a nM
Citation
 Fletcher, SR; Burkamp, F; Blurton, P; Cheng, SK; Clarkson, R; O'Connor, D; Spinks, D; Tudge, M; van Niel, MB; Patel, S; Chapman, K; Marwood, R; Shepheard, S; Bentley, G; Cook, GP; Bristow, LJ; Castro, JL; Hutson, PH; MacLeod, AM 4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists. J Med Chem 45:492-503 (2002) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52852.05
Organism:
Rattus norvegicus (rat)
Description:
Rat cortex membranes 5-HT2A receptors.
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
  
Inhibitor
Name:
BDBM50108704
Synonyms:
1'-(2,4-difluorophenethyl)-8-fluorospiro[3,4-dihydro-2H-chromene-2,4'-(hexahydropyridine)] | CHEMBL149423
Type:
Small organic molecule
Emp. Form.:
C21H22F3NO
Mol. Mass.:
361.4007
SMILES:
Fc1ccc(CCN2CCC3(CC2)CCc2cccc(F)c2O3)c(F)c1
Structure:
Search PDB for entries with ligand similarity: