Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50118806
Substrate
n/a
Meas. Tech.
ChEMBL_31847 (CHEMBL646635)
Ki
490±n/a nM
Citation
 Gao, ZG; Kim, SK; Biadatti, T; Chen, W; Lee, K; Barak, D; Kim, SG; Johnson, CR; Jacobson, KA Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary. J Med Chem 45:4471-84 (2002) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50118806
Synonyms:
CHEMBL342926 | {5-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-3-oxa-tricyclo[4.1.0.0*2,4*]hept-1-yl}-methanol
Type:
Small organic molecule
Emp. Form.:
C19H17ClIN5O2
Mol. Mass.:
509.728
SMILES:
OCC12CC1C(C1OC21)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12
Structure:
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