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Target
Neuronal acetylcholine receptor subunit beta-4
Ligand
BDBM50110263
Substrate
n/a
Meas. Tech.
ChEMBL_143393 (CHEMBL750860)
Ki
259±n/a nM
Citation
 Gohlke, H; Gündisch, D; Schwarz, S; Seitz, G; Tilotta, MC; Wegge, T Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165. J Med Chem 45:1064-72 (2002) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit beta-4
Synonyms:
ACHB4_RAT | Acrb4 | Chrnb4 | N-alpha 2 | Neuronal acetylcholine receptor non-alpha-2 chain | Neuronal acetylcholine receptor protein beta-4 subunit
Type:
Enzyme
Mol. Mass.:
55863.89
Organism:
Rattus norvegicus (Rat)
Description:
P12392
Residue:
495
Sequence:
MRGTPLLLVSLFSLLQDGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNEREQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVRSNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPTAIMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSPSTHTMASWVKECFLHKLPTFLFMKRPGLEVSLVRVPHPSQLHLATADTAATSALGPTSPSNLYGSSMYFVNPVPAAPKSAVSSHTAGLPRDARLRSSGRFREDLQEALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVFVCILGTMGLFLPPLFQIHAPSKDS
  
Inhibitor
Name:
BDBM50110263
Synonyms:
2-Pyrazin-2-yl-9-aza-bicyclo[4.2.1]non-2-ene | CHEMBL10863
Type:
Small organic molecule
Emp. Form.:
C12H15N3
Mol. Mass.:
201.2676
SMILES:
C1CC2N[C@H]1CCC=C2c1cnccn1 |c:8,THB:9:8:3:1.0|
Structure:
Search PDB for entries with ligand similarity: