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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50110715
Substrate
n/a
Meas. Tech.
ChEMBL_122778 (CHEMBL879391)
Ki
2.5±n/a nM
Citation
 Mai, A; Artico, M; Esposito, M; Sbardella, G; Massa, S; Befani, O; Turini, P; Giovannini, V; Mondovì, B 3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. J Med Chem 45:1180-3 (2002) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_BOVIN | Amine oxidase [flavin-containing] A | MAO-A | MAOA | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A | Monoamine oxidase type A
Type:
PROTEIN
Mol. Mass.:
59764.63
Organism:
Bos taurus
Description:
ChEMBL_1501477
Residue:
527
Sequence:
MESLQKTSDAGQMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARERVGGRTYTVRNEHVDYVDVGGAYVGPTQNRILRLSKQLGLETYKVNVNERLVHYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTMDNMGKEIPADAPWEAPHAVEWDKMTMKDLIEKICWTKTARQFASLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMQLLGDRVKLRSPVTYVDQSSENITVETLNRELYECRYVISAIPPTLTAKIHFRPELPSERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSLPAIMGFILARKADRLAKVHKDIRKRKICELYAKVLGSQEALHPVHYEEKNWCQEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKLSAKDIWIQEPEAEDVPAVEITPSFWERNLPSVSGLLKIVGFSTSITALWFVMYRFRLLSRS
  
Inhibitor
Name:
BDBM50110715
Synonyms:
5-Methoxymethyl-3-[4-(4,4,4-trifluoro-3-hydroxy-butoxy)-phenyl]-oxazolidin-2-one | CHEMBL18101
Type:
Small organic molecule
Emp. Form.:
C15H18F3NO5
Mol. Mass.:
349.3023
SMILES:
COC[C@@H]1CN(C(=O)O1)c1ccc(OCC[C@H](O)C(F)(F)F)cc1
Structure:
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