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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50128103
Substrate
n/a
Meas. Tech.
ChEMBL_201912 (CHEMBL808202)
Ki
2.21±n/a nM
Citation
 Berardi, F; Loiodice, F; Fracchiolla, G; Colabufo, NA; Perrone, R; Tortorella, V Synthesis of chiral 1-[omega-(4-chlorophenoxy)alkyl]-4-methylpiperidines and their biological evaluation at sigma1, sigma2, and sterol delta8-delta7 isomerase sites. J Med Chem 46:2117-24 (2003) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50128103
Synonyms:
1-[3-(4-Chloro-phenoxy)-1-methyl-propyl]-4-methyl-piperidine; hydrochloride | CHEMBL545691
Type:
Small organic molecule
Emp. Form.:
C16H24ClNO
Mol. Mass.:
281.821
SMILES:
C[C@H](CCOc1ccc(Cl)cc1)N1CCC(C)CC1
Structure:
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