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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM73402
Substrate
n/a
Meas. Tech.
ChEMBL_201910 (CHEMBL808200)
Ki
15.5±n/a nM
Citation
 Cao, J; Kulkarni, SS; Husbands, SM; Bowen, WD; Williams, W; Kopajtic, T; Katz, JL; George, C; Newman, AH Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. J Med Chem 46:2589-98 (2003) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM73402
Synonyms:
1-Phenyl-cyclopentanecarboxylic acid 2-diethylamino-ethyl ester | 1-phenyl-1-cyclopentanecarboxylic acid 2-(diethylamino)ethyl ester;hydrochloride | 1-phenylcyclopentanecarboxylic acid 2-(diethylamino)ethyl ester;hydrochloride | 2-(diethylamino)ethyl 1-phenylcyclopentane-1-carboxylate;hydrochloride | 2-(diethylamino)ethyl 1-phenylcyclopentanecarboxylate hydrochloride | CARAMIPHEN | CHEMBL61946 | MLS000532799 | SMR000140237 | cid_67173
Type:
Small organic molecule
Emp. Form.:
C18H27NO2
Mol. Mass.:
289.4125
SMILES:
CCN(CC)CCOC(=O)C1(CCCC1)c1ccccc1
Structure:
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