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Target
NH(3)-dependent NAD(+) synthetase
Ligand
BDBM50130828
Substrate
n/a
Meas. Tech.
ChEMBL_141613 (CHEMBL747929)
IC50
>200000±n/a nM
Citation
 Velu, SE; Cristofoli, WA; Garcia, GJ; Brouillette, CG; Pierson, MC; Luan, CH; DeLucas, LJ; Brouillette, WJ Tethered dimers as NAD synthetase inhibitors with antibacterial activity. J Med Chem 46:3371-81 (2003) [PubMed]  Article 
Target
Name:
NH(3)-dependent NAD(+) synthetase
Synonyms:
GSP38 | General stress protein 38 | NADE_BACSU | Spore outgrowth factor B | Sporulation protein outB | nadE | outB
Type:
PROTEIN
Mol. Mass.:
30386.77
Organism:
Bacillus subtilis
Description:
ChEMBL_141613
Residue:
272
Sequence:
MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVLGISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDKSWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDHAAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQQSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK
  
Inhibitor
Name:
BDBM50130828
Synonyms:
3-(2-{2-[2-(5-Benzyloxy-indol-1-yl)-ethoxy]-ethoxy}-ethoxycarbonyl)-1-methyl-pyridinium; iodide | CHEMBL112620
Type:
Small organic molecule
Emp. Form.:
C28H31N2O5
Mol. Mass.:
475.5556
SMILES:
C[n+]1cccc(c1)C(=O)OCCOCCOCCn1ccc2cc(OCc3ccccc3)ccc12
Structure:
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