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Target
Neurotensin receptor type 1
Ligand
BDBM50130888
Substrate
n/a
Meas. Tech.
ChEMBL_144289 (CHEMBL754790)
IC50
1.2±n/a nM
Citation
 Achilefu, S; Srinivasan, A; Schmidt, MA; Jimenez, HN; Bugaj, JE; Erion, JL Novel bioactive and stable neurotensin peptide analogues capable of delivering radiopharmaceuticals and molecular beacons to tumors. J Med Chem 46:3403-11 (2003) [PubMed]  Article 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM50130888
Synonyms:
CHEMBL408534 | alpha-FITC-DLys-Pro-Gly(PipAm)-Arg-Pro-Tyr--Ile-Leu-OH
Type:
Small organic molecule
Emp. Form.:
C74H102N16O15S
Mol. Mass.:
1487.765
SMILES:
CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C1CCCN1C(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C1CCCN1C(=O)[C@H](CCCCN)NC(=O)C1OC2(C3C=CC(=O)CC3Oc3cc(O)ccc23)c2ccc(NC(N)=S)cc12)C1CCC(CC1)C(N)=N)C(=O)NC(CC(C)C)C(O)=O |wU:49.57,c:65,(23.63,-18.8,;22.11,-18.67,;21.23,-19.93,;21.88,-21.32,;19.69,-19.8,;19.04,-18.41,;17.5,-18.27,;16.63,-19.54,;16.85,-16.89,;15.32,-16.75,;13.98,-17.52,;13.97,-19.04,;12.64,-19.8,;11.3,-19.02,;9.97,-19.78,;11.32,-17.48,;12.65,-16.72,;17.73,-15.63,;17.08,-14.23,;15.54,-14.09,;17.96,-12.97,;19.5,-12.93,;19.95,-11.46,;18.69,-10.59,;17.45,-11.52,;15.98,-11.06,;14.86,-12.13,;15.63,-9.57,;16.75,-8.52,;18.22,-8.96,;19.36,-7.91,;20.83,-8.36,;21.95,-7.31,;21.6,-5.82,;23.42,-7.77,;14.16,-9.13,;13.81,-7.63,;14.93,-6.58,;12.35,-7.17,;12,-5.68,;10.53,-5.23,;9.4,-6.28,;10.18,-3.73,;11.18,-2.57,;10.39,-1.24,;8.89,-1.59,;8.75,-3.13,;7.44,-3.93,;7.47,-5.47,;6.1,-3.18,;6.07,-1.64,;7.38,-.85,;7.35,.69,;8.68,1.48,;8.65,3.02,;4.77,-3.97,;3.43,-3.23,;3.79,-1.73,;1.94,-3.65,;1.03,-2.41,;-.44,-2.9,;.31,-1.55,;1.85,-1.5,;2.6,-.15,;1.78,1.18,;2.53,2.54,;.24,1.16,;-.51,-.22,;-2.04,-.26,;-2.79,-1.61,;-4.33,-1.64,;-5.08,-2.99,;-6.62,-3.02,;-4.27,-4.32,;-2.72,-4.29,;-1.98,-2.94,;-.41,-4.45,;-1.55,-5.5,;-1.2,-7,;.29,-7.45,;.64,-8.96,;-.51,-10.01,;-.16,-11.53,;-1.97,-9.57,;1.41,-6.41,;1.06,-4.91,;11.22,-8.22,;11.58,-9.71,;10.45,-10.76,;8.96,-10.32,;8.63,-8.82,;9.76,-7.77,;7.84,-11.37,;8.19,-12.86,;6.37,-10.9,;18.81,-21.07,;17.28,-20.93,;19.47,-22.46,;18.59,-23.73,;17.06,-23.59,;15.96,-24.68,;14.47,-24.26,;16.33,-26.17,;19.25,-25.12,;18.36,-26.38,;20.78,-25.24,)|
Structure:
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