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Target
Purine nucleoside phosphorylase
Ligand
BDBM50370246
Substrate
n/a
Meas. Tech.
ChEMBL_162193 (CHEMBL766712)
Ki
5.9±n/a nM
Citation
 Evans, GB; Furneaux, RH; Lewandowicz, A; Schramm, VL; Tyler, PC Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase. J Med Chem 46:3412-23 (2003) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50370246
Synonyms:
CHEMBL325862
Type:
Small organic molecule
Emp. Form.:
C12H16N4O4
Mol. Mass.:
280.2798
SMILES:
COC1[C@@H](O)[C@@H](CO)N[C@H]1c1c[nH]c2c1nc[nH]c2=O
Structure:
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