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Target
Major prion protein
Ligand
BDBM67545
Substrate
n/a
Meas. Tech.
ChEMBL_158887 (CHEMBL760875)
EC50
5000±n/a nM
Citation
 Vogtherr, M; Grimme, S; Elshorst, B; Jacobs, DM; Fiebig, K; Griesinger, C; Zahn, R Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem 46:3563-4 (2003) [PubMed]  Article 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM67545
Synonyms:
N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;hydrochloride | N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine;hydrochloride | N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride | PROMAZINE | SR-01000000228-4 | US9504692, Promazine | cid_5887 | dimethyl(3-phenothiazin-10-ylpropyl)amine;hydrochloride
Type:
Small organic molecule
Emp. Form.:
C17H20N2S
Mol. Mass.:
284.419
SMILES:
CN(C)CCCN1c2ccccc2Sc2ccccc12
Structure:
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