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Target
Thymidylate kinase
Ligand
BDBM50131915
Substrate
n/a
Meas. Tech.
ChEMBL_208211 (CHEMBL873990)
Ki
45000±n/a nM
Citation
 Vanheusden, V; Munier-Lehmann, H; Froeyen, M; Dugué, L; Heyerick, A; De Keukeleire, D; Pochet, S; Busson, R; Herdewijn, P; Van Calenbergh, S 3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. J Med Chem 46:3811-21 (2003) [PubMed]  Article 
Target
Name:
Thymidylate kinase
Synonyms:
KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk
Type:
PROTEIN
Mol. Mass.:
22636.29
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_208218
Residue:
214
Sequence:
MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYAELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
  
Inhibitor
Name:
BDBM50131915
Synonyms:
1-(4-Fluoromethyl-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | CHEMBL127523
Type:
Small organic molecule
Emp. Form.:
C11H15FN2O4
Mol. Mass.:
258.2462
SMILES:
Cc1cn([C@H]2C[C@H](CF)[C@@H](CO)O2)c(=O)[nH]c1=O
Structure:
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