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TargetBcl-2-like protein 1
LigandBDBM50088360
Substrate/Competitorn/a
Meas. Tech.ChEMBL_38727
IC50 2200±n/a nM
Citation Kitada, SLeone, MSareth, SZhai, DReed, JCPellecchia, M Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem46:4259-64 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bcl-2-like protein 1
Name:Bcl-2-like protein 1
Synonyms:Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | BCL2-like 1 isoform 1 | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:26039.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50088360
NameBDBM50088360
Synonyms:2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one | 2,3,4,6-tetrahydroxy-5H-benzocycloheptene-5-one | 2,3,4,6-tetrahydroxybenzocyclohepten-5-one | CHEMBL66953 | Hit compound, 2 | Purpurogallin | purpurogalline
TypeSmall organic molecule
Emp. Form.C11H8O5
Mol. Mass.220.1782
SMILESOc1cc2cccc(O)c(=O)c2c(O)c1O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a