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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50140096
Substrate
n/a
Meas. Tech.
ChEMBL_71599 (CHEMBL689131)
Ki
3±n/a nM
Citation
Guo, Z; Zhu, YF; Gross, TD; Tucci, FC; Gao, Y; Moorjani, M; Connors, PJ; Rowbottom, MW; Chen, Y; Struthers, RS; Xie, Q; Saunders, J; Reinhart, G; Chen, TK; Bonneville, AL; Chen, C Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists. J Med Chem 47:1259-71 (2004) [PubMed] Article
More Info.:
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
Inhibitor
Name:
BDBM50140096
Synonyms:
1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione | CHEMBL417645
Type:
Small organic molecule
Emp. Form.:
C29H29F3N4O3
Mol. Mass.:
538.5608
SMILES:
COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(CCN(C)CCc2ccccn2)c1=O |(7.94,4.31,;6.59,3.52,;6.62,1.96,;7.97,1.2,;7.98,-.34,;6.64,-1.12,;5.31,-.36,;5.29,1.18,;4.18,2.29,;3.99,-1.15,;3.99,-2.69,;5.34,-3.44,;2.66,-3.46,;2.68,-5,;1.33,-5.78,;1.35,-7.31,;2.42,-8.39,;.03,-8.09,;-1.32,-7.32,;-1.33,-5.78,;.01,-5.01,;-1.11,-3.89,;1.33,-2.7,;,-3.47,;1.33,-1.16,;,-.39,;-1.34,-1.17,;-2.67,-.4,;-2.68,1.14,;-4,-1.18,;-5.35,-.41,;-6.67,-1.19,;-8.01,-.41,;-9.33,-1.19,;-9.33,-2.73,;-8.01,-3.51,;-6.67,-2.73,;2.65,-.38,;2.64,1.16,)|