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Target
Motilin receptor
Ligand
BDBM50143039
Substrate
n/a
Meas. Tech.
ChEMBL_122661 (CHEMBL732791)
EC50
7.3±n/a nM
Citation
 Li, JJ; Chao, HG; Wang, H; Tino, JA; Lawrence, RM; Ewing, WR; Ma, Z; Yan, M; Slusarchyk, D; Seethala, R; Sun, H; Li, D; Burford, NT; Stoffel, RH; Salyan, ME; Li, CY; Witkus, M; Zhao, N; Rich, A; Gordon, DA Discovery of a potent and novel motilin agonist. J Med Chem 47:1704-8 (2004) [PubMed]  Article 
Target
Name:
Motilin receptor
Synonyms:
G-protein coupled receptor 38 | GPR38 | MLNR | MTLR | MTLR1 | MTLR_HUMAN
Type:
PROTEIN
Mol. Mass.:
45365.95
Organism:
Homo sapiens (Human)
Description:
ChEMBL_122664
Residue:
412
Sequence:
MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
  
Inhibitor
Name:
BDBM50143039
Synonyms:
8'N-[1-[1-carbamoyl-3-phenyl-(1R)-propylcarbamoyl]-3-phenyl-(1R)-propyl]-2'-benzo[d][1,3]dioxol-5-ylmethyl-1',3'-dioxospiro[hexahydropyridine-4,5'-perhydro[1,2,4]triazolo[1,2-a]pyridazine]-8'-carboxamide | CHEMBL298224
Type:
Small organic molecule
Emp. Form.:
C39H45N7O7
Mol. Mass.:
723.8173
SMILES:
NC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](CCc1ccccc1)NC(=O)C1CCC2(CCNCC2)n2n1c(=O)n(Cc1ccc3OCOc3c1)c2=O
Structure:
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