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Target
S-methyl-5'-thioadenosine phosphorylase
Ligand
BDBM50148132
Substrate
n/a
Meas. Tech.
ChEMBL_238 (CHEMBL615270)
Ki
1.39±n/a nM
Citation
 Evans, GB; Furneaux, RH; Schramm, VL; Singh, V; Tyler, PC Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase. J Med Chem 47:3275-81 (2004) [PubMed]  Article 
Target
Name:
S-methyl-5'-thioadenosine phosphorylase
Synonyms:
5'-Methylthioadenosine phosphorylase (MTAP) | MSAP | MTA phosphorylase | MTAP | MTAP_HUMAN | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase
Type:
Enzyme
Mol. Mass.:
31239.23
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
283
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
  
Inhibitor
Name:
BDBM50148132
Synonyms:
2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-m-tolylsulfanylmethyl-pyrrolidine-3,4-diol; 2hydrochloride | CHEMBL542449
Type:
Small organic molecule
Emp. Form.:
C18H21N5O2S
Mol. Mass.:
371.457
SMILES:
Cc1cccc(SCC2NC(C(O)C2O)c2c[nH]c3c(N)ncnc23)c1
Structure:
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