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Target
S-methyl-5'-thioadenosine phosphorylase
Ligand
BDBM50148141
Substrate
n/a
Meas. Tech.
ChEMBL_238 (CHEMBL615270)
Ki
6.4±n/a nM
Citation
 Evans, GB; Furneaux, RH; Schramm, VL; Singh, V; Tyler, PC Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase. J Med Chem 47:3275-81 (2004) [PubMed]  Article 
Target
Name:
S-methyl-5'-thioadenosine phosphorylase
Synonyms:
5'-Methylthioadenosine phosphorylase (MTAP) | MSAP | MTA phosphorylase | MTAP | MTAP_HUMAN | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase
Type:
Enzyme
Mol. Mass.:
31239.23
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
283
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
  
Inhibitor
Name:
BDBM50148141
Synonyms:
2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(3-chloro-phenylsulfanylmethyl)-pyrrolidine-3,4-diol; 2hydrochloride | CHEMBL553982
Type:
Small organic molecule
Emp. Form.:
C17H18ClN5O2S
Mol. Mass.:
391.875
SMILES:
Nc1ncnc2c(c[nH]c12)C1NC(CSc2cccc(Cl)c2)C(O)C1O
Structure:
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