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Target
Trehalase
Ligand
BDBM18351
Substrate
n/a
Meas. Tech.
ChEMBL_304922 (CHEMBL827814)
IC50
40000±n/a nM
Citation
 Godin, G; Compain, P; Martin, OR; Ikeda, K; Yu, L; Asano, N Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile. Bioorg Med Chem Lett 14:5991-5 (2004) [PubMed]  Article 
Target
Name:
Trehalase
Synonyms:
Alpha,alpha-trehalase | Alpha,alpha-trehalose glucohydrolase | TREA | TREA_HUMAN | TREH
Type:
PROTEIN
Mol. Mass.:
66559.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_208276
Residue:
583
Sequence:
MPGRTWELCLLLLLGLGLGSQEALPPPCESEIYCHGELLNQVQMAKLYQDDKQFVDMPLSIAPEQVLQTFTELSRDHNHSIPREQLQAFVHEHFQAKGQELQPWTPADWKDSPQFLQKISDAKLRAWAGQLHQLWKKLGKKMKPEVLSHPERFSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMAETVKGMLQNFLDLVKTYGHVPNGGRVYYLQRSQPPLLTLMMDCYLTHTNDTAFLQENIETLALELDFWTKNRTVSVSLEGKNYLLNRYYVPYGGPRPESYSKDVELADTLPEGDREALWAELKAGAESGWDFSSRWLIGGPNPNSLSGIRTSKLVPVDLNAFLCQAEELMSNFYSRLGNDSQATKYRILRSQRLAALNTVLWDEQTGAWFDYDLEKKKKNREFYPSNLTPLWAGCFSDPGVADKALKYLEDNRILTYQYGIPTSLQKTGQQWDFPNAWAPLQDLVIRGLAKAPLRRAQEVAFQLAQNWIRTNFDVYSQKSAMYEKYDVSNGGQPGGGGEYEVQEGFGWTNGVVLMLLDRYGDRLTSGAKLAFLEPHCLAATLLPSLLLSLLPW
  
Inhibitor
Name:
BDBM18351
Synonyms:
(2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10 | (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol | 1-Deoxynojirimycin | 1-deoxynojirimycin (DNJ) | CHEMBL307429 | US20230339856, Compound DNJ | US9181184, 1 | dNM
Type:
natural product
Emp. Form.:
C6H13NO4
Mol. Mass.:
163.1717
SMILES:
OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Structure:
Search PDB for entries with ligand similarity: