Reaction Details Report a problem with these data
Target
Neurotensin receptor type 1
Ligand
BDBM50154966
Substrate
n/a
Meas. Tech.
ChEMBL_303310 (CHEMBL840036)
Ki
>100000±n/a nM
Citation
 Bittermann, H; Einsiedel, J; Hübner, H; Gmeiner, P Evaluation of lactam-bridged neurotensin analogues adjusting psi(Pro10) close to the experimentally derived bioactive conformation of NT(8-13). J Med Chem 47:5587-90 (2004) [PubMed]  Article 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM50154966
Synonyms:
4-Methyl-2-{(S)-methyl-1-(S)-2-[(R)-2-{(R)-1-[(S)-2-((S)-2-amino-5-guanidino-pentanoylamino)-5-guanidino-1-oxo-pentyl]-6-oxo-1,7-diaza-spiro[4.4]non-7-yl}-3-(4-hydroxy-phenyl)-propionylamino]-3-oxo-pentylamino} | CHEMBL186637
Type:
Small organic molecule
Emp. Form.:
C40H66N12O8
Mol. Mass.:
843.0276
SMILES:
CC[C@H](C)[C@H](NC(=O)C(Cc1ccc(O)cc1)N1CC[C@]2(CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C1=O)C(=O)N[C@@H](CC(C)C)C(O)=O
Structure:
Search PDB for entries with ligand similarity: