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Target
Mitogen-activated protein kinase 10
Ligand
BDBM50169980
Substrate
n/a
Meas. Tech.
ChEMBL_304976 (CHEMBL829309)
IC50
65±n/a nM
Citation
 Gaillard, P; Jeanclaude-Etter, I; Ardissone, V; Arkinstall, S; Cambet, Y; Camps, M; Chabert, C; Church, D; Cirillo, R; Gretener, D; Halazy, S; Nichols, A; Szyndralewiez, C; Vitte, PA; Gotteland, JP Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase. J Med Chem 48:4596-607 (2005) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 10
Synonyms:
Jnk3 | MK10_RAT | Mapk10 | Prkm10 | c-Jun N-terminal kinase 3
Type:
PROTEIN
Mol. Mass.:
52534.34
Organism:
Rattus norvegicus
Description:
ChEMBL_1460661
Residue:
464
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSSVVKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
  
Inhibitor
Name:
BDBM50169980
Synonyms:
CHEMBL363254 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[2-(1-methyl-1H-imidazol-4-yl)-ethylamino]-pyrimidin-4-yl}-acetonitrile
Type:
Small organic molecule
Emp. Form.:
C19H17N7S
Mol. Mass.:
375.45
SMILES:
Cn1cnc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)c1
Structure:
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