Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1F
Ligand
BDBM50159187
Substrate
n/a
Meas. Tech.
ChEMBL_303711 (CHEMBL829046)
Ki
2.7±n/a nM
Citation
 Cole, DC; Lennox, WJ; Lombardi, S; Ellingboe, JW; Bernotas, RC; Tawa, GJ; Mazandarani, H; Smith, DL; Zhang, G; Coupet, J; Schechter, LE Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem 48:353-6 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1F
Synonyms:
5-HT-1F | 5-HT1F | 5-hydroxytryptamine receptor 1F | 5HT1F_HUMAN | HTR1EL | HTR1F | Serotonin (5-HT) receptor | Serotonin 1f (5-HT1f) receptor | Serotonin receptor 1F
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41724.68
Organism:
Homo sapiens (Human)
Description:
5-HT1F HTR1F HUMAN::P30939
Residue:
366
Sequence:
MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC
  
Inhibitor
Name:
BDBM50159187
Synonyms:
3-Chloro-N-[3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indol-5-yl]-benzenesulfonamide | 3-Chloro-N-[3-((S)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indol-5-yl]-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C20H22ClN3O2S
Mol. Mass.:
403.926
SMILES:
CN1CCCC1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12
Structure:
Search PDB for entries with ligand similarity: