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Target
D(4) dopamine receptor
Ligand
BDBM50159180
Substrate
n/a
Meas. Tech.
ChEMBL_303628 (CHEMBL828839)
Ki
>5000±n/a nM
Citation
 Cole, DC; Lennox, WJ; Lombardi, S; Ellingboe, JW; Bernotas, RC; Tawa, GJ; Mazandarani, H; Smith, DL; Zhang, G; Coupet, J; Schechter, LE Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem 48:353-6 (2005) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50159180
Synonyms:
2-Chloro-N-[3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indol-5-yl]-benzenesulfonamide | 2-Chloro-N-[3-((S)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indol-5-yl]-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C20H22ClN3O2S
Mol. Mass.:
403.926
SMILES:
CN1CCCC1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12
Structure:
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