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Target
Protein-S-isoprenylcysteine O-methyltransferase
Ligand
BDBM50174226
Substrate
n/a
Meas. Tech.
ChEMBL_320848 (CHEMBL884633)
Ki
13200±n/a nM
Citation
 Henriksen, BS; Anderson, JL; Hrycyna, CA; Gibbs, RA Synthesis of desthio prenylcysteine analogs: sulfur is important for biological activity. Bioorg Med Chem Lett 15:5080-3 (2005) [PubMed]  Article 
Target
Name:
Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:
Isoprenylcysteine carboxyl methyltransferase | STE14 | STE14_YEAST
Type:
PROTEIN
Mol. Mass.:
27893.87
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_321482
Residue:
239
Sequence:
MHQDFQEDEHEYPDIRRNPLHEVTMTSYILGILLGIFVGLFPQIRFKNFNLFIIALSLFHFLEYYITAKYNPLKVHSESFLLNNGKSYMAAHSFAILECLVESFLFPDLKIFSYSLATKLCTVLGCLLVILGQYTRTIAMHTAGHSFSHIVKTKKESDHVLVKTGVYSWSRHPSYLGFFWWAIGTQLLLLNPLSLVIFIFVLWKFFSDRIRVEEKYLIEFFSAEYIEYKNKVGVGIPFI
  
Inhibitor
Name:
BDBM50174226
Synonyms:
2-acetamido-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraene-1-sulfinyl]propanoate | Prenylcysteine derivative
Type:
Small organic molecule
Emp. Form.:
C25H40NO4S
Mol. Mass.:
450.655
SMILES:
[#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]S(=O)[#6]-[#6](-[#7]-[#6](-[#6])=O)-[#6](-[#8-])=O
Structure:
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