Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 1
Ligand
BDBM14210
Substrate
n/a
Meas. Tech.
ChEMBL_420094 (CHEMBL873737)
IC50
>10000±n/a nM
Citation
Jung, FH; Pasquet, G; Lambert-van der Brempt, C; Lohmann, JJ; Warin, N; Renaud, F; Germain, H; De Savi, C; Roberts, N; Johnson, T; Dousson, C; Hill, GB; Mortlock, AA; Heron, N; Wilkinson, RW; Wedge, SR; Heaton, SP; Odedra, R; Keen, NJ; Green, S; Brown, E; Thompson, K; Brightwell, S Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. J Med Chem 49:955-70 (2006) [PubMed] Article
More Info.:
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
Inhibitor
Name:
BDBM14210
Synonyms:
4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)-quinazoline | CHEMBL202721 | N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide | ZM447439
Type:
Small organic molecule
Emp. Form.:
C29H31N5O4
Mol. Mass.:
513.5875
SMILES:
COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCOCC1