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Target
Cyclin-dependent kinase 5 activator 1
Ligand
BDBM50191410
Substrate
n/a
Meas. Tech.
ChEMBL_365406 (CHEMBL867889)
IC50
>100000±n/a nM
Citation
 Ferandin, Y; Bettayeb, K; Kritsanida, M; Lozach, O; Polychronopoulos, P; Magiatis, P; Skaltsounis, AL; Meijer, L 3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents. J Med Chem 49:4638-49 (2006) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5 activator 1
Synonyms:
CDK5/p35 | Cyclin-Dependent Kinase 5 (CDK5) | Cyclin-dependent kinase 5 regulatory subunit 1 | Cyclin-dependent kinase 5/CDK5 activator 1
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 5
Synonyms:
CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Component 2
Name:
Cyclin-dependent kinase 5 activator 1
Synonyms:
CD5R1_HUMAN | CDK5R | CDK5R1 | Cyclin-Dependent Kinase 5 Activator 1, p35 | Cyclin-dependent kinase 5 (CDK5/p25) | Cyclin-dependent kinase 5 regulatory subunit 1 | NCK5A | TPKII regulatory subunit | p35
Type:
Enzyme Subunit
Mol. Mass.:
34077.43
Organism:
Homo sapiens (Human)
Description:
Q15078
Residue:
307
Sequence:
MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR
  
Inhibitor
Name:
BDBM50191410
Synonyms:
(Z)-1'-Methyl-1H,1'H-[2,3']biindolylidene-3,2'-dione 3-oxime | 3-(3-(hydroxyimino)indolin-2-ylidene)-1-methylindolin-2-one | CHEMBL366438
Type:
Small organic molecule
Emp. Form.:
C17H13N3O2
Mol. Mass.:
291.304
SMILES:
Cn1c(O)c(-c2[nH]c3ccccc3c2N=O)c2ccccc12 |(24.48,-10.48,;23.22,-9.57,;21.77,-10.04,;21.29,-11.51,;20.87,-8.8,;19.33,-8.8,;18.41,-10.06,;16.94,-9.57,;15.59,-10.34,;14.26,-9.57,;14.26,-8.03,;15.59,-7.26,;16.94,-8.03,;18.41,-7.54,;18.88,-6.09,;17.86,-4.95,;21.77,-7.56,;21.44,-6.07,;22.57,-5.02,;24.04,-5.49,;24.37,-7.01,;23.22,-8.03,)|
Structure:
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