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Target
Alpha-1B adrenergic receptor
Ligand
BDBM50187752
Substrate
n/a
Meas. Tech.
ChEMBL_384613 (CHEMBL866127)
Ki
1.1±n/a nM
Citation
 Hayashi, R; Ohmori, E; Isogaya, M; Moriwaki, M; Kumagai, H Design and synthesis of selective alpha1B adrenoceptor antagonists. Bioorg Med Chem Lett 16:4045-7 (2006) [PubMed]  Article 
Target
Name:
Alpha-1B adrenergic receptor
Synonyms:
ADA1B_RAT | Adra1b | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha adrenergic receptor 1A and 1B | Alpha-1 Adrenergic Receptor | Alpha-1Adrenoceptor | Alpha-1B adrenergic receptor | Alpha-1B adrenoreceptor | adrenergic Alpha1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
56606.71
Organism:
Rattus norvegicus (rat)
Description:
Receptor binding assays were performed using rat cortical membranes.
Residue:
515
Sequence:
MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
  
Inhibitor
Name:
BDBM50187752
Synonyms:
3-(1-(4-(piperidin-1-yl)butyl)piperidin-4-yl)-1H-indole dihydrochloride | CHEMBL557584
Type:
Small organic molecule
Emp. Form.:
C22H33N3
Mol. Mass.:
339.5175
SMILES:
C(CCN1CCC(CC1)c1c[nH]c2ccccc12)CN1CCCCC1
Structure:
Search PDB for entries with ligand similarity: