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TargetAlpha adrenergic receptor 1A and 1B
LigandBDBM50187753
Substrate/Competitorn/a
Meas. Tech.ChEMBL_384613
Ki 0.63±n/a nM
Citation Hayashi, ROhmori, EIsogaya, MMoriwaki, MKumagai, H Design and synthesis of selective alpha1B adrenoceptor antagonists. Bioorg Med Chem Lett16:4045-7 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alpha adrenergic receptor 1A and 1B
Name:Alpha adrenergic receptor 1A and 1B
Synonyms:Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha-1 Adrenergic Receptor | Alpha-1Adrenoceptor | Alpha-1B adrenergic receptor | Alpha-1B adrenoreceptor | adrenergic Alpha1B
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:56606.71
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat cortical membranes.
Residue:515
Sequence:
MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAI
VGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFM
RILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLP
SASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESP
GTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
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  Blast E-value cutoff:
BDBM50187753
NameBDBM50187753
Synonyms:6-fluoro-3-(1-(3-(piperidin-1-yl)propyl)piperidin-4-yl)-1H-indole dihydrochloride | CHEMBL541129
TypeSmall organic molecule
Emp. Form.C21H30FN3
Mol. Mass.343.4814
SMILESFc1ccc2c(c[nH]c2c1)C1CCN(CCCN2CCCCC2)CC1
Structure
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n/a