Target
GNAT family acetyltransferase
Ligand
BDBM50193474
Substrate
n/a
Meas. Tech.
ChEMBL_385423 (CHEMBL869194)
Ki
11±n/a nM
Citation
 Gao, FYan, XShakya, TBaettig, OMAit-Mohand-Brunet, SBerghuis, AMWright, GDAuclair, K Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases. J Med Chem 49:5273-81 (2006) [PubMed]  Article 
Target
Name:
GNAT family acetyltransferase
Synonyms:
Aminoglycoside acetyltransferase
Type:
PROTEIN
Mol. Mass.:
21017.80
Organism:
Enterococcus durans
Description:
ChEMBL_385423
Residue:
183
Sequence:
MIISEFDRDNLVLRDQLADLLRLTWPDEYGEQPMKEVERLLEDERIAVSAIEGDELIGFVGAIPQYGQTGWELHPLVVESMYRKQQVGTRLVSYLEKEIASQGGIVVYLGTDDVEGQTSLAIEEDLFEDTFDKLETIQNRKDHPYEFYEKLGYQIVGVIPDANGWNKPDIWMAKRIARKHGSE
  
Inhibitor
Name:
BDBM50193474
Synonyms:
(R)-4-(3-(2-(2-(((2R,3S,4R,5R,6R)-5-amino-6-((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyloxy)-3,4-dihydroxy-tetrahydro-2H-pyran-2-yl)methylamino)-2-oxoethylthio)ethylamino)-3-oxopropylamino)-3-hydroxy-2,2-dimethyl-4-oxobutyl 3-oxobutanoate | CHEMBL425612
Type:
Small organic molecule
Emp. Form.:
C29H52N6O13S
Mol. Mass.:
724.821
SMILES:
CC(=O)CC(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSCC(=O)NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
Structure:
Search PDB for entries with ligand similarity: