Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50195587
Substrate
n/a
Meas. Tech.
ChEMBL_414098 (CHEMBL908314)
Ki
1.8±n/a nM
Citation
 Semeraro, T; Lossani, A; Botta, M; Ghiron, C; Alvarez, R; Manetti, F; Mugnaini, C; Valensin, S; Focher, F; Corelli, F Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity. J Med Chem 49:6037-45 (2006) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50195587
Synonyms:
1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL | 7-((2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | CHEMBL1213652 | CHEMBL218291 | Immucillin-H
Type:
Small organic molecule
Emp. Form.:
C11H14N4O4
Mol. Mass.:
266.2533
SMILES:
OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1nc[nH]c2=O |r|
Structure:
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