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Target
Neutral cholesterol ester hydrolase 1
Ligand
BDBM50204527
Substrate
n/a
Meas. Tech.
ChEMBL_428056 (CHEMBL914788)
IC50
>100000±n/a nM
Citation
 Romero, FA; Du, W; Hwang, I; Rayl, TJ; Kimball, FS; Leung, D; Hoover, HS; Apodaca, RL; Breitenbucher, JG; Cravatt, BF; Boger, DL Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. J Med Chem 50:1058-68 (2007) [PubMed]  Article 
Target
Name:
Neutral cholesterol ester hydrolase 1
Synonyms:
AADACL1 | KIAA1363 | NCEH1 | NCEH1_HUMAN
Type:
PROTEIN
Mol. Mass.:
45810.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_835312
Residue:
408
Sequence:
MRSSCVLLTALVALAAYYVYIPLPGSVSDPWKLMLLDATFRGAQQVSNLIHYLGLSHHLLALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALASAKIRYYDELCTAMAEELNAVIVSIEYRLVPKVYFPEQIHDVVRATKYFLKPEVLQKYMVDPGRICISGDSAGGNLAAALGQQFTQDASLKNKLKLQALIYPVLQALDFNTPSYQQNVNTPILPRYVMVKYWVDYFKGNYDFVQAMIVNNHTSLDVEEAAAVRARLNWTSLLPASFTKNYKPVVQTTGNARIVQELPQLLDARSAPLIADQAVLQLLPKTYILTCEHDVLRDDGIMYAKRLESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
  
Inhibitor
Name:
BDBM50204527
Synonyms:
6-(2-(7-phenylheptanoyl)oxazol-5-yl)pyrimidine-2,4(1H,3H)-dione | CHEMBL220687
Type:
Small organic molecule
Emp. Form.:
C20H21N3O4
Mol. Mass.:
367.3984
SMILES:
O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cc(=O)[nH]c(=O)[nH]1
Structure:
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