Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50205697
Substrate
n/a
Meas. Tech.
ChEMBL_428388 (CHEMBL917988)
Ki
2.3±n/a nM
Citation
 Volpini, R; Dal Ben, D; Lambertucci, C; Taffi, S; Vittori, S; Klotz, KN; Cristalli, G N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem 50:1222-30 (2007) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50205697
Synonyms:
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(methoxyamino)-2-(pyridin-2-ylethynyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | CHEMBL223327 | N6-methoxy-2-[(2-pyridinyl)ethynyl]adenosine
Type:
Small organic molecule
Emp. Form.:
C18H18N6O5
Mol. Mass.:
398.3727
SMILES:
CONc1nc(nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)C#Cc1ccccn1
Structure:
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