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Target
Potassium voltage-gated channel subfamily D member 2
Ligand
BDBM50121975
Substrate
n/a
Meas. Tech.
ChEMBL_436810 (CHEMBL905112)
IC50
2200±n/a nM
Citation
 Plouvier, B; Beatch, GN; Jung, GL; Zolotoy, A; Sheng, T; Clohs, L; Barrett, TD; Fedida, D; Wang, WQ; Zhu, JJ; Liu, Y; Abraham, S; Lynn, L; Dong, Y; Wall, RA; Walker, MJ Synthesis and biological studies of novel 2-aminoalkylethers as potential antiarrhythmic agents for the conversion of atrial fibrillation. J Med Chem 50:2818-41 (2007) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily D member 2
Synonyms:
KCND2_RAT | Kcnd2 | RK5 | Shal1 | Voltage-gated potassium channel subunit Kv4.2
Type:
PROTEIN
Mol. Mass.:
70560.86
Organism:
Rattus norvegicus
Description:
ChEMBL_436810
Residue:
630
Sequence:
MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDNTGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEPAFVSKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKSFRIPNANVSGSHRGSVQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGGNIVRVSAL
  
Inhibitor
Name:
BDBM50121975
Synonyms:
(6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol | CARDIOQUIN | CHEMBL1294 | CIN-QUIN | DURAQUIN | QUINACT | QUINAGLUTE | QUINALAN | QUINATIME | QUINIDEX | QUINIDINE | QUINORA | US9402878, Quinidine
Type:
Small organic molecule
Emp. Form.:
C20H24N2O2
Mol. Mass.:
324.4168
SMILES:
COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 |r,THB:20:19:12.13:16.15,10:12:18.19:16.15|
Structure:
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