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Target
Leucine--tRNA ligase, cytoplasmic
Ligand
BDBM50370987
Substrate
n/a
Meas. Tech.
ChEMBL_437219 (CHEMBL906617)
IC50
2100±n/a nM
Citation
 Rock, FL; Mao, W; Yaremchuk, A; Tukalo, M; Crépin, T; Zhou, H; Zhang, YK; Hernandez, V; Akama, T; Baker, SJ; Plattner, JJ; Shapiro, L; Martinis, SA; Benkovic, SJ; Cusack, S; Alley, MR An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science 316:1759-1761 (2007) [PubMed]  Article 
Target
Name:
Leucine--tRNA ligase, cytoplasmic
Synonyms:
CDC60 | LeuRS | Leucine--tRNA ligase, cytoplasmic | Leucyl-tRNA synthetase | Leucyl-tRNA synthetase, cytoplasmic | SYLC_YEAST
Type:
PROTEIN
Mol. Mass.:
124127.98
Organism:
Saccharomyces cerevisiae S288c
Description:
ChEMBL_437218
Residue:
1090
Sequence:
MSSGLVLENTARRDALIAIEKKYQKIWAEEHQFEIDAPSIEDEPITMDSEELHRTYPKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKRALFPLGFHCTGMPILACADKLKREAELFGKNFDNVPAEEEEIKEETPAEKDHEDVTKFKAKKSKAAAKKGRGKYQFEIMLQLGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDANPYYDAFIRWQMNKLKAAGKIKFGERYTIYSEKDGQACMDHDRQSGEGVTPQEYIGVKIEALEFADDAAKIIDSSSDLDKSKKFYFVAATLRPETMYGQTCCFVSPTIEYGIFDAGDSYFITTERAFKNMSYQKLTPKRGFYKPIVTVPGKAFIGTKIHAPQSVYPELRILPMETVIATKGTGVVTCVPSNSPDDYITTKDLLHKPEYYGIKPEWIDHEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLLAEAKKIAYKEDYYTGTMIYGPYKGEKVEQAKNKVKADMIAAGEAFVYNEPESQVMSRSGDDCIVSLEDQWYVDYGEESWKKQAIECLEGMQLFAPEVKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLLFKDYYGNEIGPLGISADQMTDEVFDYIFQHQDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPKGIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITKESNLRTGEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGVMHKDLIARYIETQALLLAPIAPHFAEYIYREVLGNQTSVQNAKFPRASKPVDKGVLAALDYLRNLQRSIREGEGQALKKKKGKSAEIDASKPVKLTLLISESFPEWQSQCVEIVRKLFSEQTLDDNKKVREHIEPKEMKRAMPFISLLKQRLANEKPEDVFERELQFSEIDTVKAAARNVKKAAQALKIAEFSAISFPYGAKTGKDIFTGEEVEIPPVTKIVENAVPGNPGVVFQNI
  
Inhibitor
Name:
BDBM50370987
Synonyms:
TAVABOROLE
Type:
Small organic molecule
Emp. Form.:
C7H6BFO2
Mol. Mass.:
151.931
SMILES:
OB1OCc2cc(F)ccc12
Structure:
Search PDB for entries with ligand similarity: