Reaction Details Report a problem with these data
Target
Beta-2 adrenergic receptor
Ligand
BDBM50212729
Substrate
n/a
Meas. Tech.
ChEMBL_438806 (CHEMBL889143)
EC50
0.096000±n/a nM
Citation
 Brown, AD; Bunnage, ME; Glossop, PA; James, K; Jones, R; Lane, CA; Lewthwaite, RA; Mantell, S; Perros-Huguet, C; Price, DA; Trevethick, M; Webster, R The discovery of long acting beta2-adrenoreceptor agonists. Bioorg Med Chem Lett 17:4012-5 (2007) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50212729
Synonyms:
CHEMBL230487 | N-benzyl-2-(3-((R)-2-((R)-2-hydroxy-2-(4-hydroxy-3-(hydroxymethyl)phenyl)ethylamino)propyl)phenyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C27H32N2O4
Mol. Mass.:
448.554
SMILES:
C[C@H](Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1
Structure:
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