Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 4 group A member 2
Ligand
BDBM50371210
Substrate
n/a
Meas. Tech.
ChEMBL_453027 (CHEMBL902174)
EC50
26±n/a nM
Citation
 Hintermann, S; Chiesi, M; von Krosigk, U; Mathé, D; Felber, R; Hengerer, B Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg Med Chem Lett 17:193-6 (2006) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 4 group A member 2
Synonyms:
NOT | NR4A2 | NR4A2_HUMAN | NURR1 | TINUR
Type:
PROTEIN
Mol. Mass.:
66603.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_453027
Residue:
598
Sequence:
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
  
Inhibitor
Name:
BDBM50371210
Synonyms:
CHEMBL247879
Type:
Small organic molecule
Emp. Form.:
C22H21N3O2
Mol. Mass.:
359.421
SMILES:
CN(C)Cc1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
Structure:
Search PDB for entries with ligand similarity: