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TargetCathepsin L1
LigandBDBM50233031
Substrate/Competitorn/a
Meas. Tech.ChEMBL_462247
IC50 750±n/a nM
Citation Gauthier, JYChauret, NCromlish, WDesmarais, SDuong, le TFalgueyret, JPKimmel, DBLamontagne, SLéger, SLeRiche, TLi, CSMassé, FMcKay, DJNicoll-Griffith, DAOballa, RMPalmer, JTPercival, MDRiendeau, DRobichaud, JRodan, GARodan, SBSeto, CThérien, MTruong, VLVenuti, MCWesolowski, GYoung, RNZamboni, RBlack, WC The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett18:923-8 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin L1
Name:Cathepsin (L and K)
Synonyms:Cathepsin (L and K) | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50233031
NameBDBM50233031
Synonyms:(S)-n-(cyano-dicyclopropyl-methyl)-4,4,4-trifluoro-2-[(S)-2,2,2-trifluoro-1-(4'-methanesulfonyl-biphenyl-4-yl)-ethylamino]-butyramide | CHEMBL252784
TypeSmall organic molecule
Emp. Form.C27H27F6N3O3S
Mol. Mass.587.577
SMILESCS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)[C@H](N[C@@H](CC(F)(F)F)C(=O)NC(C#N)(C1CC1)C1CC1)C(F)(F)F
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a