Reaction Details
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Neurotensin receptor type 1
Ligand
BDBM50240845
Substrate
n/a
Meas. Tech.
ChEMBL_462692 (CHEMBL929665)
Ki
0.018±n/a nM
Citation
Einsiedel, J; Hübner, H; Hervet, M; Härterich, S; Koschatzky, S; Gmeiner, P Peptide backbone modifications on the C-terminal hexapeptide of neurotensin. Bioorg Med Chem Lett 18:2013-8 (2008) [PubMed] Article More Info.:
Target
Name:
Neurotensin receptor type 1
Synonyms:
NT-R-1 | NTR1_MOUSE | Neurotensin 1 | Neurotensin receptor 1 | Neurotensin receptor type 1 | Ntsr | Ntsr1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47237.04
Organism:
MOUSE
Description:
Neurotensin 1 NTSR1 MOUSE::A2ACT4
Residue:
424
Sequence:
MHLNSSVQQGAPSEPGAQPFPHPQFGLETMLLALSLSNGSGNSSESILEPNSNLDVNTDIYSKVLVTAVYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGLQNRSADGQHPGGLVCTPTVDTATVKVVIQVNTFMSFLFPMLIISILNTVIANKLTVMVHQAAEQGRGVCTVGTHNSLEHSTFNMSIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRRRRKKRPTFSRKPNSMSSNHAFSTSATRETLY
Inhibitor
Name:
BDBM50240845
Synonyms:
(S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amino-5-guanidino-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-methyl-pentanoic acid | 2-{(S)-2-[2-({(S)-1-[(S)-2-((S)-2-Amino-5-guanidino-pentanoylamino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-pentanoylamino}-4-(S)-methyl-pentanoic acid | CHEMBL342252 | Neurotensin(8-13)
Type:
Small organic molecule
Emp. Form.:
C38H64N12O8
Mol. Mass.:
816.9904
SMILES:
[#6]-[#6]-[#6@@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](-[#8])=O |r|
Structure:
