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TargetMelanin-concentrating hormone receptor
LigandBDBM50371868
Substrate/Competitorn/a
Meas. Tech.ChEMBL_464119
EC50 20±n/a nM
Citation Erickson, SDBanner, BBerthel, SConde-Knape, KFalcioni, FHakimi, IHennessy, BKester, RFKim, KMa, CMcComas, WMennona, FMischke, SOrzechowski, LQian, YSalari, HTengi, JThakkar, KTaub, RTilley, JWWang, H Potent, selective MCH-1 receptor antagonists. Bioorg Med Chem Lett18:1402-6 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanin-concentrating hormone receptor
Name:Melanin-concentrating hormone receptor
Synonyms:G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | Somatostatin receptor-like protein
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:45976.27
Organism:Homo sapiens (human)
Description:Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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BDBM50371868
NameBDBM50371868
Synonyms:CHEMBL269939
TypeSmall organic molecule
Emp. Form.C25H30BrN3O
Mol. Mass.468.429
SMILESCO[C@@H]1CN(C[C@H]2Cc3ccc(Br)cc3C2)CC[C@H]1n1c(C)nc2cc(C)ccc12
Structure
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n/a
NameBDBM50371868
Synonyms:CHEMBL269939
TypeSmall organic molecule
Emp. Form.C25H30BrN3O
Mol. Mass.468.429
SMILESCO[C@@H]1CN(C[C@H]2Cc3ccc(Br)cc3C2)CC[C@H]1n1c(C)nc2cc(C)ccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: