Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50372719
Substrate
n/a
Meas. Tech.
ChEMBL_465778 (CHEMBL931047)
Ki
43.4±n/a nM
Citation
 Jeong, LS; Lee, HW; Kim, HO; Tosh, DK; Pal, S; Choi, WJ; Gao, ZG; Patel, AR; Williams, W; Jacobson, KA; Kim, HD Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists. Bioorg Med Chem Lett 18:1612-6 (2008) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50372719
Synonyms:
CHEMBL428245
Type:
Small organic molecule
Emp. Form.:
C20H20ClIN6O3S
Mol. Mass.:
586.834
SMILES:
O[C@H]1[C@@H](O)[C@@H](S[C@@H]1C(=O)N1CCC1)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12
Structure:
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