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Target
Melanocortin receptor 4
Ligand
BDBM50373479
Substrate
n/a
Meas. Tech.
ChEMBL_467905 (CHEMBL925939)
IC50
0.500000±n/a nM
Citation
 Guo, L; Ye, Z; Ujjainwalla, F; Sings, HL; Sebhat, IK; Huber, J; Weinberg, DH; Tang, R; MacNeil, T; Tamvakopoulos, C; Peng, Q; MacIntyre, E; van der Ploeg, LH; Goulet, MT; Wyvratt, MJ; Nargund, RP Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators. Bioorg Med Chem Lett 18:3242-7 (2008) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R_RAT | Mc4r
Type:
PROTEIN
Mol. Mass.:
36892.87
Organism:
Rattus norvegicus
Description:
ChEMBL_11005
Residue:
332
Sequence:
MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY
  
Inhibitor
Name:
BDBM50373479
Synonyms:
CHEMBL254757
Type:
Small organic molecule
Emp. Form.:
C31H40Cl3N3O2
Mol. Mass.:
593.027
SMILES:
CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(CC1)C(=O)[C@H]1CN(C[C@@H]1c1ccc(Cl)cc1Cl)C(C)(C)C
Structure:
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