Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50373629
Substrate
n/a
Meas. Tech.
ChEMBL_468024 (CHEMBL948247)
Ki
>1000±n/a nM
Citation
 Li, G; Stamford, AW; Huang, Y; Cheng, KC; Cook, J; Farley, C; Gao, J; Ghibaudi, L; Greenlee, WJ; Guzzi, M; van Heek, M; Hwa, JJ; Kelly, J; Mullins, D; Parker, EM; Wainhaus, S; Zhang, X Discovery of novel orally active ureido NPY Y5 receptor antagonists. Bioorg Med Chem Lett 18:1146-50 (2008) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50373629
Synonyms:
CHEMBL272062
Type:
Small organic molecule
Emp. Form.:
C21H31N3O2
Mol. Mass.:
357.4897
SMILES:
CN(C1CCN(CC1)C(C)=O)C(=O)N[C@H]1CC[C@H](CC1)c1ccccc1 |wU:17.21,14.14,(3.53,-16.71,;3.53,-18.25,;4.87,-19.02,;4.86,-20.55,;6.18,-21.32,;7.52,-20.56,;7.52,-19.01,;6.19,-18.24,;8.85,-21.33,;10.19,-20.57,;8.85,-22.87,;2.2,-19.02,;2.2,-20.56,;.87,-18.25,;-.47,-19.02,;-.46,-20.55,;-1.8,-21.32,;-3.14,-20.55,;-3.13,-19.01,;-1.8,-18.24,;-4.47,-21.31,;-5.8,-20.53,;-7.14,-21.3,;-7.15,-22.84,;-5.81,-23.61,;-4.48,-22.84,)|
Structure:
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