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Target
Histone deacetylase 1
Ligand
BDBM50373675
Substrate
n/a
Meas. Tech.
ChEMBL_468074 (CHEMBL931658)
IC50
200±n/a nM
Citation
 Paquin, I; Raeppel, S; Leit, S; Gaudette, F; Zhou, N; Moradei, O; Saavedra, O; Bernstein, N; Raeppel, F; Bouchain, G; Fréchette, S; Woo, SH; Vaisburg, A; Fournel, M; Kalita, A; Robert, MF; Lu, A; Trachy-Bourget, MC; Yan, PT; Liu, J; Rahil, J; MacLeod, AR; Besterman, JM; Li, Z; Delorme, D Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors. Bioorg Med Chem Lett 18:1067-71 (2008) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50373675
Synonyms:
CHEMBL404054
Type:
Small organic molecule
Emp. Form.:
C26H26N8O
Mol. Mass.:
466.5376
SMILES:
Nc1nc(NCc2ccc(cc2)C(=O)Nc2ccccc2N)nc(NC2Cc3ccccc3C2)n1
Structure:
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