Reaction Details
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Lysophosphatidic acid receptor 2
Ligand
BDBM50373814
Substrate
n/a
Meas. Tech.
ChEMBL_468543 (CHEMBL930968)
IC50
1300±n/a nM
Citation
Beck, HP; Kohn, T; Rubenstein, S; Hedberg, C; Schwandner, R; Hasslinger, K; Dai, K; Li, C; Liang, L; Wesche, H; Frank, B; An, S; Wickramasinghe, D; Jaen, J; Medina, J; Hungate, R; Shen, W Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett 18:1037-41 (2008) [PubMed] Article More Info.:
Target
Name:
Lysophosphatidic acid receptor 2
Synonyms:
EDG4 | LPA receptor 2 | LPA-2 | LPA2 | LPAR2 | LPAR2_HUMAN | Lysophosphatidic acid receptor 2 | Lysophosphatidic acid receptor Edg-4
Type:
PROTEIN
Mol. Mass.:
39103.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1451385
Residue:
351
Sequence:
MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
Inhibitor
Name:
BDBM50373814
Synonyms:
CHEMBL270877
Type:
Small organic molecule
Emp. Form.:
C23H26F3N5O
Mol. Mass.:
445.4806
SMILES:
COc1ccccc1N1CCN(C[C@H](C)Nc2nc(nc3ccccc23)C(F)(F)F)CC1
Structure:
