Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50374096
Substrate
n/a
Meas. Tech.
ChEMBL_468943 (CHEMBL930591)
Ki
58±n/a nM
Citation
 Santora, VJ; Covel, JA; Hayashi, R; Hofilena, BJ; Ibarra, JB; Pulley, MD; Weinhouse, MI; Sengupta, D; Duffield, JJ; Semple, G; Webb, RR; Sage, C; Ren, A; Pereira, G; Knudsen, J; Edwards, JE; Suarez, M; Frazer, J; Thomsen, W; Hauser, E; Whelan, K; Grottick, AJ A new family of H3 receptor antagonists based on the natural product Conessine. Bioorg Med Chem Lett 18:1490-4 (2008) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50374096
Synonyms:
CHEMBL404753
Type:
Small organic molecule
Emp. Form.:
C27H35N3
Mol. Mass.:
401.5869
SMILES:
CN1CCN(CCc2ccc(cc2)C2=CCC3CN(Cc4ccccc4)CC23)CC1 |w:16.16,27.28,t:14|
Structure:
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