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Target
Aromatase
Ligand
BDBM50029593
Substrate
n/a
Meas. Tech.
ChEMBL_468962 (CHEMBL952107)
IC50
680±n/a nM
Citation
 Su, B; Tian, R; Darby, MV; Brueggemeier, RW Novel sulfonanilide analogs decrease aromatase activity in breast cancer cells: synthesis, biological evaluation, and ligand-based pharmacophore identification. J Med Chem 51:1126-35 (2008) [PubMed]  Article 
Target
Name:
Aromatase
Synonyms:
ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM
Type:
Enzyme
Mol. Mass.:
57888.92
Organism:
Homo sapiens (Human)
Description:
P11511
Residue:
503
Sequence:
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
  
Inhibitor
Name:
BDBM50029593
Synonyms:
CHEMBL7162 | N-(2-(cyclohexyloxy)-4-nitrophenyl)methanesulfonamide | N-(2-Cyclohexyloxy-4-nitro-phenyl)-methanesulfonamide | N-(2-Cyclohexyloxy-4-nitro-phenyl)-methanesulfonamide(NS-398) | N-[2-(cyclohexyloxy)-4-nitrophenyl]methane sulfonamide | N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulfonamide | N-{2-(cyclohexyloxy)-4-[hydroxy(oxido)amino]phenyl}methanesulfonamide | NS-398 | NS398
Type:
Small organic molecule
Emp. Form.:
C13H18N2O5S
Mol. Mass.:
314.357
SMILES:
CS(=O)(=O)Nc1ccc(cc1OC1CCCCC1)[N+]([O-])=O
Structure:
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