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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50374604
Substrate
n/a
Meas. Tech.
ChEMBL_469590 (CHEMBL934063)
Ki
10.55±n/a nM
Citation
 Mésangeau, C; Narayanan, S; Green, AM; Shaikh, J; Kaushal, N; Viard, E; Xu, YT; Fishback, JA; Poupaert, JH; Matsumoto, RR; McCurdy, CR Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity. J Med Chem 51:1482-6 (2008) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50374604
Synonyms:
CHEMBL406082 | US9604926, Compound CM-126 | US9724435, Compound CM-126
Type:
Small organic molecule
Emp. Form.:
C22H33N3O2
Mol. Mass.:
371.5163
SMILES:
O=c1oc2ccccc2n1CCCCCN1CCN(CC1)C1CCCCC1
Structure:
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