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Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50374790
Substrate
n/a
Meas. Tech.
ChEMBL_469929 (CHEMBL938398)
EC50
93±n/a nM
Citation
 Shen, L; Zhang, Y; Wang, A; Sieber-McMaster, E; Chen, X; Pelton, P; Xu, JZ; Yang, M; Zhu, P; Zhou, L; Reuman, M; Hu, Z; Russell, R; Gibbs, AC; Ross, H; Demarest, K; Murray, WV; Kuo, GH Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists. Bioorg Med Chem 16:3321-41 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50374790
Synonyms:
CHEMBL409513
Type:
Small organic molecule
Emp. Form.:
C22H24N2O3S2
Mol. Mass.:
428.568
SMILES:
Cc1ccc(cc1C)-c1nsc(CSc2ccc(OC(C)(C)C(O)=O)c(C)c2)n1
Structure:
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